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Laurent Yvan-Charvet is the Director of Research (with academic tenure in Molecular Medicine) and the Director of the “Physiopathology of Cardiometabolic Diseases” laboratory at the Department of Molecular Medicine at Nice University. He previously served as Director of Innovative Medicine Research at Pfizer’s Cardiovascular and Metabolic Diseases (CVMED) division. His laboratory has a long-standing focus on immunometabolism and its therapeutic potential in human diseases.

Dr. Yvan-Charvet earned his Ph.D. in Endocrinology in 2005 from Paris University, where he investigated novel metabolic functions of the Renin-Angiotensin System (RAS). He then pursued postdoctoral training in molecular medicine at Columbia University, New York, under the mentorship of Prof. Tall. His research there focused on the anti-inflammatory effects of High-Density Lipoprotein (HDL)-raising therapies, including macrophage and stem cell biology, within the context of cardiometabolic diseases.

Since returning to France in 2013, Dr. Yvan-Charvet established a laboratory at the Molecular Medicine Research Center of Nice University, supported by the national Atip-Avenir excellence program. His team employs a dedicated and integrated approach to identify new immunometabolic pathways, biomarkers, and therapies aimed at combating metaflammation in chronic diseases. This research has been funded by a highly competitive European Research Council (ERC) Consolidator Award and contributed to the creation of the University-Hospital Center (IHU RespirERA), which facilitates translational research, the discovery of metabolic biomarkers, and the development of innovative therapeutic strategies for diseases linked to metabolic dysfunction.

Dr. Yvan-Charvet’s laboratory has developed advanced tools for investigating molecular and cellular mechanisms in vitro and testing their relevance and causality in vivo. With over 15 years of experience in immunometabolism, the lab has received more than 200 invitations to international conferences and seminars, accumulating over 15,000 citations. This extensive work has positioned the lab as a leader in the field, with high levels of conceptual and technical expertise in immunometabolism.
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