Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue. | Yvan-Charvet L, Massiéra F, Lamandé N, Ailhaud G, Teboul M, Moustaid-Moussa N, Gasc JM, Quignard-Boulangé A. | Endocrinology. 2009 | 2008/10/25 | Endocrinology | Cardiometabolism |
Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. | Yvan-Charvet L, Even P, Bloch-Faure M, Guerre-Millo M, Moustaid-Moussa N, Ferre P, Quignard-Boulange A. | Diabetes. 2005 | 2005/03/29 | Endocrinology | Cardiometabolism |
Gender-related response of lipid metabolism to dietary fatty acids in the hamster. | Morise A, Mourot J, Boué C, Combe N, Amsler G, Gripois D, Quignard-Boulangé A, Yvan-Charvet L, Fénart E, Weill P, Hermier D. | Br J Nutr. 2006 | 2006/03/31 | Endocrinology | Cardiometabolism |
Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. | Lagathu C, Yvan-Charvet L, Bastard JP, Maachi M, Quignard-Boulangé A, Capeau J, Caron M. | Diabetologia. 2006 | 2006/07/26 | Endocrinology | Cardiometabolism |
Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice. | Yvan-Charvet L, Even P, Lamandé N, Ferré P, Quignard-Boulangé A. | Endocrinology. 2006 | 2006/08/05 | Endocrinology | Cardiometabolism |
Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow. | Ranalletta M, Wang N, Han S, Yvan-Charvet L, Welch C, Tall AR. | Arterioscler Thromb Vasc Biol. 2006 | 2006/08/19 | Immunometabolism | Cardiometabolism |
The failure of torcetrapib: was it the molecule or the mechanism? | Tall AR, Yvan-Charvet L, Wang N. | Arterioscler Thromb Vasc Biol. 2007 | 2007/01/19 | Clinical | Cardiometabolism |
In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis. | Yvan-Charvet L, Bobard A, Bossard P, Massiéra F, Rousset X, Ailhaud G, Teboul M, Ferré P, Dagher G, Quignard-Boulangé A. | Arterioscler Thromb Vasc Biol. 2007 | 2007/03/17 | Endocrinology | Cardiometabolism |
Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. | Cui D, Thorp E, Li Y, Wang N, Yvan-Charvet L, Tall AR, Tabas I. | J Leukoc Biol. 2007 | 2007/06/20 | Immunometabolism | Cardiometabolism |
High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. | Terasaka N, Wang N, Yvan-Charvet L, Tall AR. | Proc Natl Acad Sci U S A. 2007 | 2007/09/12 | Immunometabolism | Cardiometabolism |
SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. | Yvan-Charvet L, Pagler TA, Wang N, Senokuchi T, Brundert M, Li H, Rinninger F, Tall AR. | J Lipid Res. 2008 | 2007/10/26 | Immunometabolism | Cardiometabolism |
[Raising HDL-cholesterol: the future drug therapy for atherosclerosis?]. | Masson D, Yvan-Charvet L. | Med Sci (Paris). 2008 | 2008/04/15 | Clinical | Cardiometabolism |
Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. | Yvan-Charvet L, Welch C, Pagler TA, Ranalletta M, Lamkanfi M, Han S, Ishibashi M, Li R, Wang N, Tall AR. | Circulation. 2008 | 2008/10/15 | Immunometabolism | Cardiometabolism |
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. | Yvan-Charvet L, Wang N, Tall AR. | Arterioscler Thromb Vasc Biol. 2010 | 2009/10/03 | Immunometabolism | Cardiometabolism |
Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. | Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, Sparrow CP, Taggart AK, Tall AR. | Arterioscler Thromb Vasc Biol. 2010 | 2010/05/08 | Clinical | Cardiometabolism |
Role of adipose tissue renin-angiotensin system in metabolic and inflammatory diseases associated with obesity. | Yvan-Charvet L, Quignard-Boulangé A. | Kidney Int. 2011 | 2010/10/15 | Endocrinology | Cardiometabolism |
Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. | Kuo CL, Murphy AJ, Sayers S, Li R, Yvan-Charvet L, Davis JZ, Krishnamurthy J, Liu Y, Puig O, Sharpless NE, Tall AR, Welch CL. | Arterioscler Thromb Vasc Biol. 2011 | 2011/08/27 | Immunometabolism | Cardiometabolism |
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. | Murphy AJ, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo CL, Wang M, Sanson M, Abramowicz S, Welch C, Bochem AE, Kuivenhoven JA, Yvan-Charvet L, Tall AR. | J Clin Invest. 2011 | 2011/10/05 | Hematometabolism | Cardiometabolism |
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. | Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L. | Circulation. 2012 | 2012/04/18 | Clinical | Cardiometabolism |
Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. | Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. | Circ Res. 2013 | 2013/04/11 | Immunometabolism | Cardiometabolism |
Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage? | Hasty AH, Yvan-Charvet L. | Circ Res. 2013 | 2013/11/10 | Immunometabolism | Cardiometabolism |
ATP-binding cassette transporters, atherosclerosis, and inflammation. | Westerterp M, Bochem AE, Yvan-Charvet L, Murphy AJ, Wang N, Tall AR. | Circ Res. 2014 | 2014/01/05 | Immunometabolism | Cardiometabolism |
Understanding macrophage diversity at the ontogenic and transcriptomic levels. | Gautier EL, Yvan-Charvet L. | Immunol Rev. 2014 | 2014/10/17 | Immunometabolism | Immunology |
Cholesterol, inflammation and innate immunity. | Tall AR, Yvan-Charvet L. | Nat Rev Immunol. 2015 | 2015/01/24 | Immunometabolism | Immunology |
Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes. | Tondu AL, Robichon C, Yvan-Charvet L, Donne N, Le Liepvre X, Hajduch E, Ferré P, Dugail I, Dagher G. | J Biol Chem. 2005 | 2005/07/22 | Endocrinology | Cardiometabolism |
ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. | Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, Tabas I, Tall AR. | Circ Res. 2010 | 2010/05/01 | Immunometabolism | Cardiometabolism |
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. | Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. | Nat Med. 2013 | 2013/04/16 | Hematometabolism | Cardiometabolism |
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. | Dehn S, DeBerge M, Yeap XY, Yvan-Charvet L, Fang D, Eltzschig HK, Miller SD, Thorp EB. | J Immunol. 2016 | 2016/09/28 | Immunometabolism | Cardiometabolism |
Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE(-/-) Mice. | Sarrazy V, Viaud M, Westerterp M, Ivanov S, Giorgetti-Peraldi S, Guinamard R, Gautier EL, Thorp EB, De Vivo DC, Yvan-Charvet L. | Circ Res. 2016 | 2016/03/02 | Hematometabolism | Cardiometabolism |
Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases? | Yvan-Charvet L, Swirski FK. | Eur Heart J. 2018 | 2018/05/18 | Hematometabolism | Cardiometabolism |
The modern interleukin-1 superfamily: Divergent roles in obesity. | Lee MK, Yvan-Charvet L, Masters SL, Murphy AJ. | Semin Immunol. 2016 | 2016/10/12 | Immunometabolism | Cardiometabolism |
Poststatin era in atherosclerosis management: lessons from epidemiologic and genetic studies. | Yvan-Charvet L, Cariou B. | Curr Opin Lipidol. 2018 | 2018/03/20 | Clinical | Cardiometabolism |
Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. | Yvan-Charvet L, Matsuura F, Wang N, Bamberger MJ, Nguyen T, Rinninger F, Jiang XC, Shear CL, Tall AR. | Arterioscler Thromb Vasc Biol. 2007 | 2007/02/27 | Clinical | Cardiometabolism |
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. | Yvan-Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, Welch C, Tall AR. | J Clin Invest. 2007 | 2007/11/10 | Immunometabolism | Cardiometabolism |
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. | Wang N, Yvan-Charvet L, Lütjohann D, Mulder M, Vanmierlo T, Kim TW, Tall AR. | FASEB J. 2008 | 2007/11/28 | Immunometabolism | Cardiometabolism |
HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. | Tall AR, Yvan-Charvet L, Terasaka N, Pagler T, Wang N. | Cell Metab. 2008 | 2008/05/08 | Immunometabolism | Cardiometabolism |
ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | Terasaka N, Yu S, Yvan-Charvet L, Wang N, Mzhavia N, Langlois R, Pagler T, Li R, Welch CL, Goldberg IJ, Tall AR. | J Clin Invest. 2008 | 2008/10/18 | Endometabolism | Cardiometabolism |
ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. | Yvan-Charvet L, Pagler T, Gautier EL, Avagyan S, Siry RL, Han S, Welch CL, Wang N, Randolph GJ, Snoeck HW, Tall AR. | Science. 2010 | 2010/05/22 | Hematometabolism | Cardiometabolism |
ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. | Terasaka N, Westerterp M, Koetsveld J, Fernández-Hernando C, Yvan-Charvet L, Wang N, Sessa WC, Tall AR. | Arterioscler Thromb Vasc Biol. 2010 | 2010/08/28 | Endometabolism | Cardiometabolism |
[HDL and its transporters ABCA1 and ABCG1 regulate innate immunity and hematopoietic stem cell proliferation]. | Gautier EL, Yvan-Charvet L. | Med Sci (Paris). 2011 | 2011/02/09 | Hematometabolism | Cardiometabolism |
Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells. | Murphy AJ, Westerterp M, Yvan-Charvet L, Tall AR. | Biochim Biophys Acta. 2012 | 2011/08/26 | Hematometabolism | Cardiometabolism |
Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. | Westerterp M, Gourion-Arsiquaud S, Murphy AJ, Shih A, Cremers S, Levine RL, Tall AR, Yvan-Charvet L. | Cell Stem Cell. 2012 | 2012/08/07 | Hematometabolism | Cardiometabolism |
Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis. | Tall AR, Yvan-Charvet L, Westerterp M, Murphy AJ. | Arterioscler Thromb Vasc Biol. 2012 | 2012/10/19 | Hematometabolism | Cardiometabolism |
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. | Gautier EL, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lütjohann D, Randolph GJ, Levine RL, Tall AR, Yvan-Charvet L. | J Exp Med. 2013 | 2013/01/16 | Hematometabolism | Cancer |
Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis. | Ganda A, Magnusson M, Yvan-Charvet L, Hedblad B, Engström G, Ai D, Wang TJ, Gerszten RE, Melander O, Tall AR. | Circulation. 2013 | 2013/02/05 | Clinical | Cardiometabolism |
Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice. | Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L. | Arterioscler Thromb Vasc Biol. 2014 | 2014/02/08 | Hematometabolism | Cardiometabolism |
Adipose modulation of ABCG1 uncovers an intimate link between sphingomyelin and triglyceride storage. | Murphy AJ, Yvan-Charvet L. | Diabetes. 2015 | 2015/02/26 | Endocrinology | Cardiometabolism |
Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation. | Sarrazy V, Sore S, Viaud M, Rignol G, Westerterp M, Ceppo F, Tanti JF, Guinamard R, Gautier EL, Yvan-Charvet L. | Cell Rep. 2015 | 2015/09/29 | Immunometabolism | Cardiometabolism |
Can LDL cholesterol be too low? Possible risks of extremely low levels. | Olsson AG, Angelin B, Assmann G, Binder CJ, Björkhem I, Cedazo-Minguez A, Cohen J, von Eckardstein A, Farinaro E, Müller-Wieland D, Parhofer KG, Parini P, Rosenson RS, Starup-Linde J, Tikkanen MJ, Yvan-Charvet L. | J Intern Med. 2017 | 2017/03/16 | Clinical | Cardiometabolism |
Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD. | Ganda A, Yvan-Charvet L, Zhang Y, Lai EJ, Regunathan-Shenk R, Hussain FN, Avasare R, Chakraborty B, Febus AJ, Vernocchi L, Lantigua R, Wang Y, Shi X, Hsieh J, Murphy AJ, Wang N, Bijl N, Gordon KM, de Miguel MH, Singer JR, Hogan J, Cremers S, et al. | J Mol Cell Cardiol. 2017 | 2017/05/10 | Clinical | Cardiometabolism |
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity. | Westerterp M, Gautier EL, Ganda A, Molusky MM, Wang W, Fotakis P, Wang N, Randolph GJ, D'Agati VD, Yvan-Charvet L, Tall AR. | Cell Metab. 2017 | 2017/05/10 | Immunometabolism | Immunology |
Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production. | Viaud M, Ivanov S, Vujic N, Duta-Mare M, Aira LE, Barouillet T, Garcia E, Orange F, Dugail I, Hainault I, Stehlik C, Marchetti S, Boyer L, Guinamard R, Foufelle F, Bochem A, Hovingh KG, Thorp EB, Gautier EL, Kratky D, Dasilva-Jardine P, Yvan-Charvet L. | Circ Res. 2018 | 2018/03/11 | Immunometabolism | Cardiometabolism |
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype. | Ohanna M, Cerezo M, Nottet N, Bille K, Didier R, Beranger G, Mograbi B, Rocchi S, Yvan-Charvet L, Ballotti R, Bertolotto C. | Genes Dev. 2018 | 2018/03/24 | Immunometabolism | Cancer |
Immunometabolism of Phagocytes and Relationships to Cardiac Repair. | Zhang S, Bories G, Lantz C, Emmons R, Becker A, Liu E, Abecassis MM, Yvan-Charvet L, Thorp EB. | Front Cardiovasc Med. 2019 | 2019/04/30 | Immunometabolism | Cardiometabolism |
Macrophage Origin, Metabolic Reprogramming and IL-1 Signaling: Promises and Pitfalls in Lung Cancer. | Guilbaud E, Gautier EL, Yvan-Charvet L. | Cancers (Basel). 2019 | 2019/03/06 | Immunometabolism | Cancer |
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair. | Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB. | Cell Metab. 2019 | 2019/01/01 | Immunometabolism | Cardiometabolism |
Cholesterol Mass Efflux Capacity, Incident Cardiovascular Disease, and Progression of Carotid Plaque. | Shea S, Stein JH, Jorgensen NW, McClelland RL, Tascau L, Shrager S, Heinecke JW, Yvan-Charvet L, Tall AR. | Arterioscler Thromb Vasc Biol. 2019 | 2018/12/26 | Clinical | Cardiometabolism |
Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. | Gilleron J, Bouget G, Ivanov S, Meziat C, Ceppo F, Vergoni B, Djedaini M, Soprani A, Dumas K, Jacquel A, Yvan-Charvet L, Venteclef N, Tanti JF, Cormont M. | Cell Rep. 2018 | 2018/12/20 | Immunometabolism | Cardiometabolism |
Immunometabolic function of cholesterol in cardiovascular disease and beyond. | Yvan-Charvet L, Bonacina F, Guinamard RR, Norata GD | Cardiovasc Res. 2019 | 2019/07/01 | Immunometabolism | Cardiometabolism |
Mesothelial cell CSF1 sustains peritoneal macrophage proliferation. | Ivanov S, Gallerand A, Gros M, Stunault MI, Merlin J, Vaillant N, Yvan-Charvet L, Guinamard RR. | Eur J Immunol. 2019 | 2019/11 | Immunometabolism | Immunology |
Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act. | Yvan-Charvet L, Ng LG. | Trends Immunol. 2019 | 2019/07 | Hematometabolism | Immunology |
[Does sleep preserve blood vessels?]. | Yvan-Charvet L, Merlin J. | Med Sci (Paris). 2019 | 2019/10/18 | Hematometabolism | Cardiometabolism |
REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet. | Dumas K, Ayachi C, Gilleron J, Lacas-Gervais S, Pastor F, Favier FB, Peraldi P, Vaillant N, Yvan-Charvet L, Bonnafous S, Patouraux S, Anty R, Tran A, Gual P, Cormont M, Tanti JF, Giorgetti-Peraldi S. | FASEB J. 2020 | 2020/04 | Immunometabolism | NASH |
ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms. | Viaud M, Abdel-Wahab O, Gall J, Ivanov S, Guinamard R, Sore S, Merlin J, Ayrault M, Guilbaud E, Jacquel A, Auberger P, Wang N, Levine RL, Tall AR, Yvan-Charvet L. | Cell Rep. 2020 | 2020/03/10 | Hematometabolism | Cancer |
Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism. | Lee MKS, Dragoljevic D, Bertuzzo Veiga C, Wang N, Yvan-Charvet L, Murphy AJ. | Trends Endocrinol Metab. 2020 | 2020/07 | Hematometabolism | Cardiometabolism |
Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis. | Tran S, Baba I, Poupel L, Dussaud S, Moreau M, Gélineau A, Marcelin G, Magréau-Davy E, Ouhachi M, Lesnik P, Boissonnas A, Le Goff W, Clausen BE, Yvan-Charvet L, Sennlaub F, Huby T, Gautier EL. | Immunity. 2020 | 2020/09/15 | Immunometabolism | NASH |
Liver X receptors are required for thymic resilience and T cell output. | Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK. | J Exp Med. 2020 | 2020/10/05 | Immunometabolism | Immunology |
Metabolic Inflammation in Obesity-At the Crossroads between Fatty Acid and Cholesterol Metabolism. | Curley S, Gall J, Byrne R, Yvan-Charvet L, McGillicuddy FC. | Mol Nutr Food Res. 2020 | 2021/01 | Immunometabolism | Cardiometabolism |
Metabolic Reprogramming of Macrophages in Atherosclerosis: Is It All about Cholesterol? | Yvan-Charvet L, Ivanov S. | J Lipid Atheroscler. 2020 | 2020/05 | Immunometabolism | Cardiometabolism |
The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again | Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, Checler F, Chevillard S, Cristofari G, Demory M, Esnault V, Falandry C, Gilson E, Guérin O, Glaichenhaus N, Guigay J, Ilié M, Mari B, Marquette CH, Paquis-Flucklinger V, Prate F, Saintigny P, et al. | Cancers (Basel). 2019 | 2019/02/24 | Clinical | Cancer |